Paula Francezca C. Padua
St. Luke’s Medical Center, Philippines
Title: Venolymphatic malformation in a 4 year old male, treated with picibanil (ok-432) with systemic inflammatory response syndrome as a complication: A Case Report
Biography
Biography: Paula Francezca C. Padua
Abstract
Objective:
(1) To present a case of venolymphatic malformation and OK-432 as its management
(2) To discuss the mechanism of action of OK-432 in the treatment of venolymphatic malformations
(3) To discuss the known complications of OK-432 in the treatment of venolymphatic malformations
Design: Case Report
Setting: Tertiary Hospital in Metro Manila
Case Report: A 4 year old male, presenting with a right facial and cervicothoracic mass, consulted and given Picibanil (OK-432) as trial treatment for 2 doses. A local inflammatory response was observed after the first dose. However, the patient exhibited a systemic inflammatory response after the 2nd dose.
Conclusion: Venolymphatic malformation is one of the most common types of vascular malformations with an overall prevalence of up to 1% in the general population. Although benign, these lesions have a tendency to grow in an infiltrating manner. OK-432, which is the most widely used alternative treatment, showed promising results of regression of malformations, systemic inflammatory response syndrome may be a possible side effect with its use.