Pediatrics, Pediatric Gastroenterology and Nutrition

Background Neonatal infection is one of the most common disease in Neonatal intensive care unit, and is also a crucial cause of neonatal death. An effectual therapy at the very beginning of the infection can significantly reduce the mortality of neonate. Object To uncover the status of neonatal infection and current antibiotic therapeutic proposal. Method An observational, retrospective study was performed, assessing all the infants that were dead during hospitalization between 2013.1.1-2014.12.31. Analyze the clinical data,  discover the risk factors and characteristics of infection, and summarize the current precaution and therapeutic proposal. Result 40(91%) out of 44 in total infants had infective symptom, and 68% of their mothers got infective symptom too, and only 38% of these mothers received antibiotic therapy, while the drug had low sensitivity and the duration of use was not correct. 35(88%) out of 40 infected infants received antibiotic therapy, while 5(12%) infants were unable to received effective therapy due to the unobvious clinical symptom and early on set of death. The positive rate of clinical pathogen samples was 17%, most of which was Klebsiella pneumonia Streptococcus viridans and Escherichia coli. Piperacillin tazobactam sodium and Meropenem is most common used. Conclusion Infection occupies a crucial role in neonatal death, by improving maternal infection treatment and enhancing the management of infants can significantly reduce neonatal mortality.